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RSS FeedsIJMS, Vol. 20, Pages 4071: Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents (International Journal of Molecular Sciences)

 
 

21 august 2019 14:00:20

 
IJMS, Vol. 20, Pages 4071: Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents (International Journal of Molecular Sciences)
 


Whole exome analyses have identified a number of genes associated with autism spectrum disorder (ASD) and ASD-related syndromes. These genes encode key regulators of synaptogenesis, synaptic plasticity, cytoskeleton dynamics, protein synthesis and degradation, chromatin remodeling, transcription, and lipid homeostasis. Furthermore, in silico studies suggest complex regulatory networks among these genes. Drosophila is a useful genetic model system for studies of ASD and ASD-related syndromes to clarify the in vivo roles of ASD-associated genes and the complex gene regulatory networks operating in the pathogenesis of ASD and ASD-related syndromes. In this review, we discuss what we have learned from studies with vertebrate models, mostly mouse models. We then highlight studies with Drosophila models. We also discuss future developments in the related field.


 
268 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 4072: Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 4070: Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function (International Journal of Molecular Sciences)
 
 
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