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RSS FeedsIJERPH, Vol. 16, Pages 3020: Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis (International Journal of Environmental Research and Public Health)

 
 

21 august 2019 18:00:06

 
IJERPH, Vol. 16, Pages 3020: Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis (International Journal of Environmental Research and Public Health)
 




Observational studies and randomised controlled studies suggest that vitamin D plays a role in the prevention of acute respiratory tract infection (ARTI); however, findings are inconsistent and the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration remains unclear. To review the link between 25(OH)D concentration and ARTI, we searched PubMed and EMBASE databases to identify observational studies reporting the association between 25(OH)D concentration and risk or severity of ARTI. We used random-effects meta-analysis to pool findings across studies. Twenty-four studies were included in the review, 14 were included in the meta-analysis of ARTI risk and five in the meta-analysis of severity. Serum 25(OH)D concentration was inversely associated with risk and severity of ARTI; pooled odds ratios (95% confidence interval) were 1.83 (1.42–2.37) and 2.46 (1.65–3.66), respectively, comparing the lowest with the highest 25(OH)D category. For each 10 nmol/L decrease in 25(OH)D concentration, the odds of ARTI increased by 1.02 (0.97–1.07). This was a non-linear trend, with the sharpest increase in risk of ARTI occurring at 25(OH)D concentration < 37.5 nmol/L. In conclusion, there is an inverse non-linear association between 25(OH)D concentration and ARTI.


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15 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 16, Pages 3019: Optimizing School Food Supply: Integrating Environmental, Health, Economic, and Cultural Dimensions of Diet Sustainability with Linear Programming (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 16, Pages 3017: The Influence of Standardized Residency Training on Trainees` Willingness to Become a Doctor: A Comparison between Traditional Chinese Medicine and Western Medicine (International Journal of Environmental Research and Public Health)
 
 
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