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22 august 2019 11:00:12

 
Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER (Molecular Cell)
 


Msp1 extracts mistargeted tail-anchored (TA) proteins from the mitochondrial outer membrane for reinsertion into the ER membrane. The ER-membrane-inserted TA proteins are then subjected to the ER quality control system, i.e., ubiquitination by Doa10 and subsequent re-extraction by Cdc48 to the cytosol for proteasomal degradation.


 
221 viewsCategory: Molecular Biology, Cell Biology
 
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