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RSS FeedsGlucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake (Cell Metabolism)

 
 

22 august 2019 20:00:50

 
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake (Cell Metabolism)
 




Adriaenssens et al. identified cells expressing receptors for the gut hormone GIP in human and mouse hypothalamus using a new Gipr-Cre mouse model and RNAscope. Local hypothalamic delivery of AAVs expressing Cre-dependent Gq-DREADDs revealed that activation of Gipr-positive neurons in mice reduced food consumption.


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