Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake (Cell Metabolism)

Adriaenssens et al. identified cells expressing receptors for the gut hormone GIP in human and mouse hypothalamus using a new Gipr-Cre mouse model and RNAscope. Local hypothalamic delivery of AAVs expressing Cre-dependent Gq-DREADDs revealed that activation of Gipr-positive neurons in mice reduced food consumption.