Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission (Cell Host & Microbe)

Simian to human lentiviral transmissions require adaptations in tetherin antagonism by viral Nef proteins. Buffalo et al. present the cryo-EM structure of SIV Nef complexed with tetherin and AP-2, providing insight into the importance of the tetherin DIWK motif and its role as a barrier to SIV spread in humans.