Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features (Cell Host & Microbe)

Virulence determinants of the human-restricted pathogen Salmonella Typhi are incompletely understood. Karlinsey et al. use a high-density transposon library to identify genes required for S. Typhi virulence in humanized mice engrafted with human immune cells. The screen reveals key differences between S. Typhimurium and S. Typhi pathogenesis.