First-line Immuno-Oncology Combination Therapies in Metastatic Renal-cell Carcinoma: Results from the International Metastatic Renal-cell Carcinoma Database Consortium (European Urology)
Using the International Metastatic Renal-cell Carcinoma Database Consortium database, we reviewed 188 patients with metastatic renal-cell carcinoma who received first-line ipilimumab and nivolumab (ipi-nivo) versus immuno-oncology/vascular endothelial growth factor (VEGF) combinations. There were no significant differences in first-line outcomes between groups. Response rates to second-line VEGF-based treatments were higher in patients who received ipi-nivo.