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RSS FeedsDHHC5 mediates beta-adrenergic signaling in cardiomyocytes by targeting G? proteins (Biophysical Journal)

 
 

23 august 2019 08:03:04

 
DHHC5 mediates beta-adrenergic signaling in cardiomyocytes by targeting G? proteins (Biophysical Journal)
 


S-palmitoylation is a reversible posttranslational modification that plays an important role in regulating protein localization, trafficking, and stability. Recent studies have shown that some proteins undergo extremely rapid palmitoylation/depalmitoylation cycles after cellular stimulation supporting a direct signaling role for this post-translational modification. Here we investigated whether ?-adrenergic stimulation of cardiomyocytes led to stimulus-dependent palmitoylation of downstream signaling proteins.


 
226 viewsCategory: Biophysics
 
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