Cell Biology
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23 august 2019 14:02:58 |
| A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas (Developmental Cell) |
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Tweet Murakami et al. demonstrate the stage-dependent requirement for Yap in PDAC maintenance. Yap knockout causes tumor regression and regeneration of pancreatic parenchyma in early-stage PDAC but only temporarily halts tumor growth in advanced p53 mutant PDAC tumors due to de-repression of Sox2, which substitutes for Yap in maintaining metabolic homeostasis. |
| 181 viewsCategory: Cell Biology |
 LEFKOTHEA Regulates Nuclear and Chloroplast mRNA Splicing in Plants (Developmental Cell)Publisher Correction: HER2 joins AKT to inhibit STING immunity (Nature Cell Biology) 
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