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RSS FeedsSweet rescue or surrender of the failing heart? [Molecular Bases of Disease] (Journal of Biological Chemistry)

 
 

23 august 2019 14:03:05

 
Sweet rescue or surrender of the failing heart? [Molecular Bases of Disease] (Journal of Biological Chemistry)
 


Natriuretic peptides (NPs) are hormones involved in maintaining heart health that undergo proteolytic cleavage to become activated. Previous work has shown that O-GalNAc glycans affect their processing and activation. Here, Goetze, Schjoldager, and colleagues now provide comprehensive characterization of O-glycosylation of NPs, revealing that all members of the NP family can be modified by O-GalNAc glycans. Intriguingly, the study discovers glycans in the receptor-binding region of the A-type natriuretic peptide (ANP), demonstrating that they affect both stability and activity of ANP. These results may inform future therapeutic approaches for heart failure using peptide glycoforms.


 
158 viewsCategory: Biochemistry
 
Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor [Molecular Bases of Disease] (Journal of Biological Chemistry)
In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way [Cell Biology] (Journal of Biological Chemistry)
 
 
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