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RSS FeedsLMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL (Cancer Cell)

 
 

23 august 2019 15:04:26

 
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL (Cancer Cell)
 


Parvin et al. show that LMO2 inhibits BRCA1 recruitment to DNA double-strand breaks (DSB) by interacting with 53BP1. Thus, diffuse large B cell lymphomas expressing LMO2 are functionally deficient in homologous recombination-mediated DSB repair and are sensitive to poly(ADP-ribose) polymerase inhibitors.


 
193 viewsCategory: Cell Biology, Oncology
 
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