A Refined View on the Association Between Y-chromosome Microdeletions and Sperm Concentration (European Urology)

Infertility is a global health issue that affects up to 15% of couples, with a male factor as a contributing cause in 20-70% of cases [1]. Semen analysis is an essential first step in the evaluation of male infertility, with further evaluation and treatment determined on the basis of the results. However, male infertility is a complex and heterogeneous condition for which the etiology is often unknown. Many of the idiopathic cases of male infertility are thought to be due to unknown genetic defects, as thousands of genes contribute to spermatogenesis [2].