Withdrawal: Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling. [Withdrawals/Retractions] (Journal of Biological Chemistry)

VOLUME 284 (2009) PAGES 17120-17128This article has been withdrawn by the authors. The Journal raised questions that the Akt immunoblot in Fig. 2A was reused in Fig. 5B; lanes 1, 2, and 4 of the actin immunoblot in Fig. 4A are the same; the LKB1 immunoblot in Fig. 7B was reused in Fig. 7D; and lane 2 of the tubulin immunoblot in Fig. 9A was reused in lane 1 for Fig. 9C. The authors were able to locate some of the original data and were able to locate some repeated experiments performed at the time of the original work, which the authors state support the conclusions of the paper. The authors offered to publish amended figures based upon that data and, alternatively, offered to repeat the experiments. However, the Journal declined both offers, a decision with which the authors disagree. Further, the authors state that the results of this paper are confirmed by the results of complementary experiments presented in the article and that some of the principal observations of this article were further confirmed in publications from other laboratories (Soliman, H. et al. (2015) Am. J. Physiol. Heart Circ. Physiol. 309, H70-H81; Lee, S-H. et al. (2014) Am. J. Physiol. Endocrinol. Metab. 306, E332-E343). The authors stand by the conclusions of the paper.