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RSS FeedsT Cell Activation Depends on Extracellular Alanine (Cell Reports)

 
 

17 september 2019 17:03:17

 
T Cell Activation Depends on Extracellular Alanine (Cell Reports)
 




In health, T lymphocytes are in a resting state. However, stimulation with their cognate antigen induces massive growth and proliferation. Ron-Harel et al. demonstrate that T cells rely on extracellular alanine for activation. Consumed alanine is used primarily for protein synthesis, and alanine deprivation inhibits T cell metabolism and effector functions.


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15 viewsCategory: Cell Biology
 
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