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RSS FeedsRUNX1-ETO Depletion in t(8;21) AML Leads to C/EBP?- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction (Cell Reports)

 
 

17 september 2019 17:03:17

 
RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBP?- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction (Cell Reports)
 




Promoter-Capture Hi-C assays, gene expression, and transcription-factor binding data are used to construct a RUNX1-ETO-dependent dynamic gene regulatory network that maintains acute myeloid leukemia (AML). Ptasinska et al. show that RUNX1-ETO participates in cis-regulatory element interactions and that differential interactions after RUNX1-ETO depletion are driven by C/EBP? and AP-1.


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16 viewsCategory: Cell Biology
 
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