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RSS FeedsDecision-Making in Cascade Complexes Harboring crRNAs of Altered Length (Cell Reports)

 
 

17 september 2019 17:03:17

 
Decision-Making in Cascade Complexes Harboring crRNAs of Altered Length (Cell Reports)
 




Songailiene et al. show that engineered versions of Cascade with elongated crRNAs can base-pair with target DNA over 57 bp. However, target recognition only requires wild-type-sized base-pairing of ~30-bp length. These findings define constraints for improving the specificity of these complexes in biotechnological applications.


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28 viewsCategory: Cell Biology
 
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