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RSS FeedsDual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks (Cell Reports)

 
 

17 september 2019 17:03:17

 
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks (Cell Reports)
 




Cristini et al. identify a mechanism of DSB formation in non-replicating cells, which strictly depends on transcription. They are formed by two single-strand breaks on opposing DNA strands resulting from the processing of both R-loops and topoisomerase I, and genetic defects increasing these transcriptional DSBs cause neurological disorders.


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35 viewsCategory: Cell Biology
 
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