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RSS FeedsMitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies (Cancer Cell)

 
 

15 october 2019 04:00:16

 
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies (Cancer Cell)
 


Guièze et al. show that resistance to the BCL-2 inhibitor venetoclax in chronic lymphocytic leukemia is associated with complex clonal shifts and identify, in addition to the known involvement by BCL-2 family members, regulators of lymphoid transcription and cellular energy metabolism as resistance drivers.


 
206 viewsCategory: Cell Biology, Oncology
 
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