Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy (Cell Reports)

Kim et al. express a genetically encoded electron microscopy (EM) tag in mRGCs of the mouse retina and use serial block-face electron microscopy to analyze the optic nerve and synaptic neuropil in five different brain regions. They find that mRGC synaptic terminals show target-specific specializations corresponding to differences in responses to light.