HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1?, and Hsc70 (Cell Reports)

Luo et al. use class IIa HDAC inhibitors, along with skeletal-muscle-specific and whole-body inducible HDAC4 knockout mice, to demonstrate HDAC4 deacetylates three previously undescribed substrates: myosin heavy chain, PGC-1?, and Hsc70. Through these substrates, HDAC4 inhibition leads to rescue of muscle atrophy and increased succinate dehydrogenase activity.