What Goes Up Must Come Down: Identifying Truth from Global Prostate Cancer Epidemiology (European Urology)

Global trends for prostate cancer incidence and mortality are driven by several important factors. In this issue of European Urology, Culp and colleagues [1] demonstrate that prostate cancer incidence has largely declined worldwide over the last 5 yr. Prostate cancer-specific mortality rates have largely plateaued; however, there are important differences in incidence and prostate cancer-specific mortality between developed and developing nations. Prostate cancer incidence, which in 2019 probably reflects regional practices for prostate-specific antigen (PSA) screening, tends to be higher in developed countries in North America, Western Europe, and Australia.