A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway (Molecular Cell)

Efficient degradation of protein aggregates, damaged mitochondria, or intracellular pathogens is key for cellular homeostasis. Their specific elimination is mediated by selective autophagy receptors (SARs) that bind to their cargo, triggering the formation of an autophagosome. In their Review, Kirkin and Rogov discuss SAR biology with a special focus on the interactions of SARs with ubiquitin-like proteins.