Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization (Cell)

Structures of the full-length P2X7 receptor provide the first insights into the architecture and function of a P2X receptor cytoplasmic domain, which includes a unique cytoplasmic ballast fold containing a zinc ion complex and a guanosine nucleotide binding site as well as an understanding of how palmitoylation of the C-cys anchor prevents receptor desensitization.