Companion Diagnostics to Identify Biomarkers of Response to Anticancer Drugs Targeting the Proteome (Cancer Cell)

In this issue of Cancer Cell, Pillarsetty and colleagues radiolabel the potential anticancer drug PU-H71 and use it with PET imaging to quantify the epichaperome protein complex in tumors and its inhibition by the drug. They thereby develop a companion diagnostic paradigm of probe-drug pairing to explore therapeutic potential.