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RSS FeedsSmall-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy (Cancer Cell)

 
 

12 november 2019 01:03:44

 
Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy (Cancer Cell)
 


Han et al. develop inhibitors that disrupt MYC/MAX heterodimerization, enhance MYC degradation, and impair MYC-driven gene expression. One compound exhibits potent anti-tumor efficacy in mice with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy.


 
246 viewsCategory: Cell Biology, Oncology
 
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