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12 november 2019 01:03:44

 
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo (Cancer Cell)
 


Bai et al. develop SD-36, a proteolysis targeting chimera (PROTAC) that selectively degrades STAT3 and inhibits the growth of leukemia and lymphoma cell lines. SD-36 is well tolerated in immune-competent mice and induces durable tumor regression in vivo in xenograft models.


 
259 viewsCategory: Cell Biology, Oncology
 
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