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RSS FeedsIJMS, Vol. 20, Pages 5672: The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model (International Journal of Molecular Sciences)

 
 

12 november 2019 23:03:03

 
IJMS, Vol. 20, Pages 5672: The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model (International Journal of Molecular Sciences)
 


Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the tumor, Sema3C function remains controversial. In this study, we constructed a stably overexpressing Sema3C glioblastoma cell line U87 MG and tested it on the chicken embryo chorioallantoic membrane (CAM) model with the aim to reveal Sema3C protein function on angiogenesis process in ovo. Our experiments showed that Sema3C not only affects angiogenesis of CAM by inhibiting neovascularization but also acts as an anti-tumorigenic molecule by hampering U87 MG cell invasion into mesenchyme. The effects of Sema3C on CAM were similar to the effects of anti-epileptic drug sodium valproate (NaVP). Both, anti-angiogenic and anti-tumorigenic activities of Sema3C were enhanced by the treatment of NaVP and, importantly, were not attributed to the cytotoxic effects. Our studies suggest that Sema3C could be a promising target for glioblastoma treatment.


 
172 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 5659: Trends in Atopic Dermatitis--From Standard Pharmacotherapy to Novel Drug Delivery Systems (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 5671: Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System (International Journal of Molecular Sciences)
 
 
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