Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson`s Disease (Cell Reports)

Hertel et al. demonstrate complex alterations in human and microbial sulfur metabolism in Parkinson`s disease by integrating longitudinal metabolomics and computational modeling of gut microbiomes. Then, potential clinical importance is revealed as secondary taurine-conjugated bile acids are shown to be associated with disease severity and Parkinson`s disease incidence.