DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency (Cell Reports)

McLaughlin et al. demonstrate that the global DNA methylation state directs the PRC-dependent 3D organization of mouse ESCs and probably early blastocysts. Their findings highlight a central role for DNA methylation and its influence on polycomb, in shaping major aspects of 3D genome organization in stem cells.