Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4 (Cell Reports)

An et al. report that polycistronic Sox2 and Klf4 induced pluripotency in multiple cell types, and the factor stoichiometry and cooperativity are essential for pluripotency network activation. This work demonstrates a core function of Sox2 and Klf4 in pluripotency induction and a mechanism independent of germ layer origin.