Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking (Cell Reports)

Yammine et al. propose lipocalin-2 (Lcn2) as a regulator of EGFR activity. By binding to TGF-?-activated EGFR intracellular domain, cytosolic Lcn2 enhances its recycling to the cell surface. This accounts for EGFR sustained activation leading to chronic kidney disease and makes Lcn2 a potential therapeutic target in this context.