Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-??R-/- Mice (Cell Host & Microbe)

A safe and efficient vaccine that protects fetuses against ZIKV is critically needed. In this paper, Larocca et al. show in mice that adenovirus vector-based ZIKV vaccines elicit high titers of anti-ZIKV neutralizing antibodies and confer protection to the pregnant mother, the fetus in utero, and the infant after birth.