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18 november 2019 18:00:07

 
Cell Biology: Hacking Alpha Satellites out of the HAC (Current Biology)
 


Human artificial chromosomes (HACs) are a potentially powerful technique for genomic engineering, but their use is limited by the repetitive centromeric alpha-satellite DNA needed to form a centromere. A new study presents a method to induce HAC centromere formation on non-repetitive templates through sequence-directed CENP-A nucleosome seeding.


 
154 viewsCategory: Biology
 
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