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RSS FeedsN-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis (Developmental Cell)

 
 

18 november 2019 23:00:55

 
N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis (Developmental Cell)
 


Pancreatic ductal adenocarcinoma is highly metastatic; recycling of the receptor LPAR1 drives metastasis in response to self-generated chemotactic gradients of LPA. Juin et al. show that the signaling adapter protein N-WASP coordinates recycling of LPAR1 back to the cell surface after internalization, driving efficient matrix remodeling, invasion, and tumor egress.


 
276 viewsCategory: Cell Biology
 
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