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RSS FeedsIJMS, Vol. 20, Pages 5824: Molecular Interactions between Pathogens and the Circadian Clock (International Journal of Molecular Sciences)


21 november 2019 15:00:31

IJMS, Vol. 20, Pages 5824: Molecular Interactions between Pathogens and the Circadian Clock (International Journal of Molecular Sciences)

The daily periodicity of the Earth’s rotation around the Sun, referred to as circadian (Latin “circa” = about, and “diem” = day), is also mirrored in the behavior and metabolism of living beings. The discovery that dedicated cellular genes control various aspects of this periodicity has led to studies of the molecular mechanism of the circadian response at the cellular level. It is now established that the circadian genes impact on a large network of hormonal, metabolic, and immunological pathways, affecting multiple aspects of biology. Recent studies have extended the role of the circadian system to the regulation of infection, host–pathogen interaction, and the resultant disease outcome. This critical review summarizes our current knowledge of circadian-pathogen interaction at both systemic and cellular levels, but with emphasis on the molecular aspects of the regulation. Wherever applicable, the potential of a direct interaction between circadian factors and pathogenic macromolecules is also explored. Finally, this review offers new directions and guidelines for future research in this area, which should facilitate progress. Digg Facebook Google StumbleUpon Twitter
12 viewsCategory: Biochemistry, Biophysics, Molecular Biology
IJMS, Vol. 20, Pages 5826: CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 5823: Heat Shock Cognate 70 Functions as A Chaperone for the Stability of Kinetochore Protein CENP-N in Holocentric Insect Silkworms (International Journal of Molecular Sciences)
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