SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation (Molecular Cell)

Psakhye et al. uncover that SUMO chains specifically counteracted by the Ulp2 SUMO protease function like a countdown timer when they are assembled on substrates of the Slx5/Slx8 SUMO-targeted ubiquitin ligase (STUbL), which channels them for proteasomal degradation, as demonstrated here for SUMOylated DDK engaged in DNA replication initiation.