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21 november 2019 20:00:54

 
SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation (Molecular Cell)
 




Psakhye et al. uncover that SUMO chains specifically counteracted by the Ulp2 SUMO protease function like a countdown timer when they are assembled on substrates of the Slx5/Slx8 SUMO-targeted ubiquitin ligase (STUbL), which channels them for proteasomal degradation, as demonstrated here for SUMOylated DDK engaged in DNA replication initiation.


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39 viewsCategory: Molecular Biology, Cell Biology
 
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