MyJournals Home  

RSS FeedsMurine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging [RESOURCES] (Genome Research)

 
 

2 december 2019 21:03:01

 
Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging [RESOURCES] (Genome Research)
 




Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals are composed of distinct cell type identities and tissue environments, but the influence of these cell identities and environments on the trajectory of aging in individual cells remains unclear. Here, we performed single-cell RNA-seq on >50,000 individual cells across three tissues in young and old mice to allow for direct comparison of aging phenotypes across cell types. We found transcriptional features of aging common across many cell types, as well as features of aging unique to each type. Leveraging matrix factorization and optimal transport methods, we found that both cell identities and tissue environments exert influence on the trajectory and magnitude of aging, with cell identity influence predominating. These results suggest that aging manifests with unique directionality and magnitude across the diverse cell identities in mammals.


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
108 viewsCategory: Bioinformatics, Genetics, Genomics
 
Discovery of high-confidence human protein-coding genes and exons by whole-genome PhyloCSF helps elucidate 118 GWAS loci [RESOURCES] (Genome Research)
The C. elegans 3` UTRome v2 resource for studying mRNA cleavage and polyadenylation, 3`-UTR biology, and miRNA targeting [RESOURCES] (Genome Research)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Genomics

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2019 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn