Watch Out for Those Terrible Twos! Dinucleotide Accumulation Dysregulates Mitochondrial Transcription (Molecular Cell)

In this issue of Molecular Cell, Nicholls et al. (2019) show that the oligoribonuclease REXO2 degrades mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome, shedding new light on the importance of complete RNA degradation for transcriptional integrity.