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RSS FeedsIntratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells (Cancer Cell)

 
 

9 december 2019 19:03:15

 
Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells (Cancer Cell)
 


Etxeberria et al. engineer tumor-specific CD8+ T cells that transiently express IL-12 to mitigate toxicity and show that intratumoral injection of these engineered T cells in conjunction with local CD137 co-stimulation leads to epitope spreading and regression of injected and distant lesions in solid tumor models.


 
234 viewsCategory: Cell Biology, Oncology
 
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