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RSS FeedsIJERPH, Vol. 16, Pages 5030: Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice (International Journal of Environmental Research and Public Health)

 
 

10 december 2019 23:03:35

 
IJERPH, Vol. 16, Pages 5030: Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice (International Journal of Environmental Research and Public Health)
 




Microcystin-LR (MC-LR) is a potent hepatotoxin, but a few studies suggested that it might also induce nephrotoxicity. However, nephrotoxicity induced by prolonged oral exposure to MC-LR is unknown. The aim of this study was to evaluate the potential influence of MC-LR on the kidney in mice following chronic exposure to MC-LR. In this study, we evaluated the nephrotoxicity of MC-LR in mice drinking water at different concentrations (1, 30, 60, 90, and 120 μg/L) for 6 months for the first time. The results showed that the kidney weights and the kidney indexes of mice were not altered in the MC-LR treated mice, compared with the control group. In addition, the renal function indicators revealed that the serum creatinine (SCr) levels were not significant changes after exposure to MC-LR. The blood urea nitrogen (BUN) levels were markedly decreased after exposure to 90 and 120μg/L MC-LR for 3 months. The BUN levels were lower than that of the control group after exposure to 120μg/L MC-LR for 6 months. The histopathological investigation revealed enlarged renal corpuscles, widened of kidney tubules, and lymphocyte infiltration in the interstitial tissue and the renal pelvis after exposure to 60, 90, and 120 μg/L MC-LR. Consequently, our results suggested that long-term exposure to MC-LR might be one important risk of kidney injury, which will provide important clues for the prevention of renal impairment.


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51 viewsCategory: Medicine, Pathology, Toxicology
 
IJERPH, Vol. 16, Pages 5031: A Multi-Criteria Decision-Making Model for Evaluating Senior Daycare Center Locations (International Journal of Environmental Research and Public Health)
IJERPH, Vol. 16, Pages 5029: Development of Physical Performance Tasks during Rapid Growth in Brazilian Children: The Cariri Healthy Growth Study (International Journal of Environmental Research and Public Health)
 
 
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