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RSS FeedsCompromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection (Cell Reports)

 
 

11 december 2019 04:00:09

 
Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection (Cell Reports)
 


T cell dysfunction contributes to the development of many chronic infections and cancer. Russell et al. show that chronic Mtb infection leads to a progressive decline in the metabolic health of effector T cells that reside in lung lesions. This metabolic reprograming can be reversed by treatment with metformin.


 
247 viewsCategory: Cell Biology
 
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