Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages (Cell Reports)

Borah et al. measured nitrogen uptake and assimilation in Mycobacterium tuberculosis during replication in host macrophages using 15N-flux spectral ratio analysis (15N-FSRA), a systems-based tool. The biosynthetic and transport systems of the identified nitrogen sources involved in serine biosynthesis are potential drug targets.