On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons (Cell Reports)

Local protein synthesis in axons supplies new ribosomal proteins far from the nucleolus, the known site of ribosome biogenesis. Shigeoka et al. provide evidence that axonally synthesized ribosomal proteins join pre-existing ribosomes and maintain translation activity in axons, which is required for axon terminal branching.