Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay (Cell Reports)

Drosophila neuroblast selection is an epithelial-mesenchymal transition (EMT)-like process, gated by the Notch pathway. However, the interplay between the Notch and EMT pathways was unclear. Arefin et al. characterize an expanded Notch pathway, involving SoxB and Snail genes acting as proneural genes, that intersects with EMT, via crumbs, to orchestrate neuroblast selection.