Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure (Cell Reports)

del Río-Martín et al. show that lack of innervation of the suprachiasmatic nucleus by retinal axons prevents light-dependent entrainment of central and peripheral circadian clocks. Consequently, cyclic behavioral, metabolic, and endocrine outputs are permanently altered and resistant to rescue by metabolic entrainment via food-restricted feeding.