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RSS FeedsThe Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function (Cell Reports)

 
 

11 december 2019 04:00:09

 
The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function (Cell Reports)
 


Rai et al. define roles for the DNA replisome components Claspin, PCNA, and DONSON in the sensing and repair of telomeres lacking POT1-TPP1. In cells lacking MRN, CPD initiates DNA-PKcs-mediated p-CHK1 activation and A-NHEJ repair. Claspin directly interacts with TRF2 and recruits EXO1 to promote 5´ C-strand end resection.


 
239 viewsCategory: Cell Biology
 
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