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RSS FeedsIJMS, Vol. 20, Pages 6241: Do Mutations Turn p53 into an Oncogene? (International Journal of Molecular Sciences)

 
 

11 december 2019 10:03:42

 
IJMS, Vol. 20, Pages 6241: Do Mutations Turn p53 into an Oncogene? (International Journal of Molecular Sciences)
 


The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers, and germline mutations expose carriers to cancer risk throughout their lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53, but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.


 
207 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 20, Pages 6242: Osteogenic Differentiation of Human Adipose Tissue-Derived MSCs by Non-Toxic Calcium Poly(ethylene phosphate)s (International Journal of Molecular Sciences)
IJMS, Vol. 20, Pages 6240: Renal Chemerin Expression is Induced in Models of Hypertensive Nephropathy and Glomerulonephritis and Correlates with Markers of Inflammation and Fibrosis (International Journal of Molecular Sciences)
 
 
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