Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice (Cell Host & Microbe)

Molecular determinants of the human B cell response to avian influenza N9 neuraminidase (NA) proteins, which differ from seasonal virus NAs, are ill-defined. Gilchuk et al. identify antibodies to multiple protective antigenic sites on N9 NA that block egress of nascent virions from infected cells and mediate protection in mice.