Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila (Cell Host & Microbe)

Liu et al. show that feces of subjects with multiple sclerosis (MS) and animals with EAE are enriched with microRNAs, such as miR-30d, with therapeutic properties. miR-30d suppresses EAE when given orally by expanding the commensal Akkermansia muciniphila through upregulation of a ?-galactosidase, which increases regulatory T cells to suppress disease.