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RSS FeedsEMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration (Developmental Cell)

 
 

18 june 2018 18:01:27

 
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration (Developmental Cell)
 


Using a lineage-traced tumor model, Aiello et al. describe a program of epithelial-to-mesenchymal transition (EMT), conserved across several carcinomas, involving re-localization of epithelial proteins rather than transcriptional repression. This alternative program leads to a `partial EMT` phenotype that promotes collective tumor cell migration and formation of circulating tumor cell clusters.


 
141 viewsCategory: Cell Biology
 
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